Tamara Bidone

Post Doctoral Scholar
Department of Chemistry
University of Chicago
tamarabidone_at_uchicago.edu

Tamara received her PhD in biomedical engineering in 2013 from the Polytechnic University of Turin, Italy. While a graduate student, Tamara joined the Kamm’s lab at MIT and Aznar’s lab at the University of Zaragoza, and worked on a computational model of actomyosin self-organization. After graduation, Tamara joined Vavylonis’ group in Lehigh University to work on a model of contractile ring assembly in collaboration with experimental groups (D. Zhang, Temasek Life Science Laboratory in Singapore, and J.Q. Wu, Ohio State University). While at Lehigh University, Tamara was instructor of the course of Computational Physics. She subsequently joined Voth’s group at the University of Chicago in 2016, to work on a model of focal adhesions.

Research Interests

My research interests are in the field of multiscale simulations of biological assemblies, where the current focus is on coupling molecular dynamics with coarse graining approaches and Brownian Dynamics. While most of my previous experience is in developing Brownian Dynamics algorithms to study actomyosin dynamics and build up of tension in contractile disordered networks, in Voth’s group I am developing a multi scale computational framework to study focal adhesions. Specifically, I am parametrizing a Brownian Dynamics model based on kinetics information from the molecular and coarse grain dynamics.  

List of publications

  1. Dan Zhang, Tamara C. Bidone, Dimitrios Vavylonis, “ER-PM conctacts define actomyosin kinetics for proper contractile ring assembly”, Curr. Biol. 2016 Mar 7; 26(5): 647-53. doi: 10.1016/j.cub.2015.12.070
  2. Haosu Tang, Tamara C. Bidone, Dimitrios Vavylonis, “Computational model of actin cable and contractile ring formation in budding yeast”, Cytoskeleton (Hoboken), 2015 Oct; 72(10):517-33, doi: 10.1002/cm.21258
  3. Tamara C. Bidone, Taeyoon Kim, Marco A. Deriu, Umberto Morbiducci, Roger D. Kamm, “Multiscale impact of nucleotides and cations on the conformational equilibrium, elasticity and rheology of actin filaments and crosslinked networks”, Biomech Model Mechan. 2015 Oct;14(5):1143-55. doi: 10.1007/s10237-015-0660-6.
  4. Tamara C. Bidone. Haosu Tang, Dimitrios Vavylonis, “Dynamic network morphology and tension buildup in 3D model of cytokinetic ring assembly”, Biophys J., 107: 2618-2628, 2014.
  5. Carlos Borau, Taeyoon Kim, Tamara C. Bidone, José Manuel García-Aznar, Roger D. Kamm, “Dynamic mechanisms of cell rigidity sensing: insights from a computational model of actomyosin networks”, PLoS ONE 7(11): e49174. doi:10.1371/journal.pone.0049174.
  6. Deriu M.A., Shkurti A., Paciello G., Bidone T.C., Morbiducci U., Ficarra E., Audenino A., Acquaviva A., “Multiscale Modelling of Cellular Actin Filaments: From Atomistic Molecular to Coarse Grained Dynamics”, Proteins, Bertrand Garcia-Moreno, pp. 12, 2012, ISSN: 1097-0134.
  7. Deriu M.A., Bidone T.C., Mastrangelo F., Di Benedetto G., Soncini M., Montevecchi F.M., Morbiducci U., “Biomechanics of actin filaments: a computational multi-level study”, J Biomech, Elsevier, pp. 7, 2011, Vol. 44, ISSN: 0021-9290, DOI: 10.1016/j.jbiomech.2010.11.014.