Glen Hocky

Post Doctoral Scholar
Department of Chemistry
University of Chicago
hockyg_at_uchicago.edu

Glen received a B.S. in Mathematics and a B.S. in Chemistry (with Honors) at the University of Chicago in 2009. He received his Ph.D. in 2014 from Columbia University, studying the origin of slow dynamics in supercooled liquids with Prof. David Reichman. He joined the Voth group in August 2014.

Research interests:

My postdoctoral research interests broadly involve the applications of techniques from statistical mechanics and molecular modeling to better understand the mechanisms behind biological processes, particularly those involving interactions between macromolecules. 

Publications

  • Phosphomimetic S3D-Cofilin Binds but Does Not Sever Actin Filaments.  W. Austin Elam*, Wenxiang Cao*, Hyeran Kang, Andrew Huehn, Glen M. Hocky, Ewa Prochniewicz, Anthony C. Schramm, Karina Nieves-Torres, Jean Garcia, Teresa Bonello, Thomas Fath, Peter W. Gunning, David D. Thomas, Gregory A. Voth, Charles V. Sindelar, and Enrique M. De La Cruz In revision (2017) 
  • Mechanosensitive Inhibition of Formin Facilitates Contractile Ring Assembly in Fission Yeast.  Dennis Zimmermann, Kaitlin E. Homa*, Glen M. Hocky*, Luther W. Pollard, Enrique M. De La Cruz, Gregory A. Voth, Matthew J. Lord, Kathleen M. Trybus, and David R. Kovar Nature Comm., in press (2017) 
  • Coarse-Grained Directed Simulation.  Glen M. Hocky, Thomas Dannenhoffer-Lafage, and Gregory A. Voth J. Chem. Theor. Comput. 13 (9), 4593-4603 (2017) 
  • A Versatile Method for Simulating the Dynamic Mechanical Structure of Cytoskeletal Networks.  Simon Freedman, Shiladitya Banerjee, Glen M. Hocky, and Aaron R. Dinner Biophys. J, (113) 2, 448-460 (2017) 
  • Actin Filament Strain Promotes Severing and Cofilin Dissociation.  Anthony C. Schramm, Glen M. Hocky, Gregory A. Voth, Laurent Blanchoin, Jean-Louis Martiel, and Enrique M. De La Cruz Biophys. J. (112) 12, 2624-2633 (2017) 
  • Competition Between Tropomyosin, Fimbrin, And ADF/Cofilin Drives Their Sorting to Distinct Actin Filament Networks.  Jenna R. Christensen, Glen M. Hocky, Kaitlin E. Homa, Alisha N. Morganthaler, Sarah E. Hitchcock-DeGregori, Gregory A. Voth, and David R. Kovar eLife 2017;10.7554/eLife.23152 (2017) 
  • Communication: Improved Ab Initio Molecular Dynamics by Minimal Biasing with Experimental Data.  Andrew D. White, Christopher Knight, Glen M. Hocky, and Gregory A. Voth J. Chem. Phys. 146, 041102 (2017) 
  • Fascin- and Alpha-Actinin-Bundled Networks Contain Intrinsic Structural Features That Drive Protein Sorting.  Jonathan D. Winkelman*, Cristian Suarez*, Glen M. Hocky, Alyssa J. Harker, Alisha N. Morganthaler, Jenna R. Christensen, Gregory A. Voth, James R. Bartles, and David R. Kovar Curr. Biol. (26) 20, 2697 (2016) 
  • Cations Stiffen Actin Filaments by Adhering a Key Structural Element to Adjacent Subunits.  Glen M. Hocky*, Joseph L. Baker*, Michael J. Bradley, Anton V. Sinitskiy, Enrique M. De La Cruz, and Gregory A. Voth J. Phys. Chem. B. 120 (20), 4558-4567 (2016) 
  • The F-Actin Bundler Alpha-Actinin Ain1 Is Tailored for Ring Assembly and Constriction During Cytokinesis in Fission Yeast.  Yujie Li, Jenna R. Christensen*, Kaitlin E. Homa*, Glen M. Hocky, Alice Fok, Jennifer A. Sees, Gregory A. Voth, and David R. Kovar. Mol. Biol. Cell. 27 (11), 1821-1833 (2016) 
  • Exploring Valleys Without Climbing Every Peak: More Efficient and Forgiving Metabasin Metadynamics via Robust On-the-Fly Bias Domain Restriction.  James F. Dama, Glen M. Hocky, Rui Sun, and Gregory A. Voth J. Chem. Theor. Comput. 11 (12), 5638-5650 (2015) 
  • Equilibrium Ultrastable Glasses Produced by Random Pinning.  Glen M. Hocky, Ludovic Berthier, and David R. Reichman J. Chem. Phys. 141, 224503 (2014) 
  • Correlation of Local Order with Particle Mobility in Supercooled Liquids is Highly System Dependent.  Glen M. Hocky, Daniele Coslovich, Atsushi Ikeda, and David R. Reichman Phys. Rev. Lett. 113, 157801 (2014) 
  • Crossovers in The Dynamics of Supercooled Liquids Probed by An Amorphous Wall.  Glen M. Hocky, Ludovic Berthier, Walter Kob, and David R. Reichman Phys. Rev. E 89, 052311 (2014) 
  • A Small Subset of Normal Modes Mimics the Properties of Dynamical Heterogeneity in A Model. Supercooled Liquid.  Glen M. Hocky and David R. Reichman J. Chem. Phys. 138, 12A537 (2013) 
  • Growing Point-To-Set Length Scale Correlates with Growing Relaxation Times in Model Supercooled Liquids.  Glen M. Hocky, Thomas E. Markland, and David R. Reichman Phys. Rev. Lett. 108, 22506 (2012) 
  • Protein Structure Prediction Enhanced with Evolutionary Diversity: SPEED.  Joe DeBartolo, Glen Hocky, Michael Wilde, Jinbo Xu, Karl F. Freed, and Tobin R. Sosnick Prot. Sci. 19 (3), 520-534 (2010) 
  • Towards Petascale Ab Initio Protein Folding Through Parallel Scripting.  Glen Hocky, Michael Wilde, Joe DeBartolo, Mihael Hategan, Ian Foster, Tobin R. Sosnick, and Karl F. Freed Argonne technical report, MCS-P1645-0609 (2009) 
  • Influence of Nonlinear Electrostatics on Transfer Energies Between Liquid Phases: Charge Burial Is Far Less Expensive Than Born Model.  Haipeng Gong, Glen Hocky, and Karl F. Freed Proc. Natl. Acad. Sci. 105 (32), 11146-11151 (2008)