Korbinian Liebl

CCTCh Fellow
Chicago Center for Theoretical Chemistry
The University of Chicago
kliebl@uchicago.edu
Google Scholar

Korbinian studied Physics at the Technical University of Munich, where he earned his B.S., M.S. and Ph.D. in 2014, 2016 and 2020. During his Ph.D., he studied the mechanics of DNA using Molecular Dynamics simulations and other theoretical concepts, and also parameterized a new DNA force field. Afterwards, he joined a biochemistry group to engineer new interleukine proteins for therapeutical purposes. Korbinian joined the Voth group as a postdoctoral scholar in July 2022 due to a CCTCh fellowship. His research interests lie in in the multiscale theory to simulate large-scale processes, and in the development of new simulation methods.

 

Publications:

  1. Korbinian Liebl, Tomas Drsata, Filip Lankas, Jan Lipfert, Martin Zacharias, Explaining the striking difference in twist-stretch coupling between DNA and RNA: A comparative molecular dynamics analysis, Nucleic Acids Research, Volume 43, Issue 21, 2015, Pages 10143–10156
  2. Korbinian Liebl and Martin Zacharias, Unwinding Induced Melting of Double-Stranded DNA Studied by Free Energy Simulations, The Journal of Physical Chemistry B, Volume 121, Issue 49, 2017, Pages 11019-11030
  3. Korbinian Liebl, Martin Zacharias, How methyl–sugar interactions determine DNA structure and flexibility, Nucleic Acids Research, Volume 47, Issue 3, 2019, Pages 1132–1140
  4. Korbinian Liebl, Martin Zacharias, How global DNA unwinding causes non-uniform stress distribution and melting of DNA, PLoS ONE, Volume 15, Issue 5, 2020
  5. Asmar Nayis, Korbinian Liebl, Christina Frost and Martin Zacharias, Targeting Telomeres: Molecular Dynamics and Free Energy Simulation of Gold-Carbene Binding to DNA, Biophysical Journal, Volume 120, Issue 1, 2021, Pages 101-108
  6. Korbinian Liebl, Martin Zacharias, Accurate modeling of DNA conformational flexibility by a multivariate Ising model, PNAS, Volume 118, Issue 15, 2021
  7. Korbinian Liebl, Martin Zacharias, Tumuc1: A new accurate DNA force field consistent with high-level quantum chemistry, JCTC, Volume 17, Issue 11, 2021
  8. Ulrich Grupa, Korbinian Liebl, Martin Zacharias, Orientation dependence of DNA blunt end stacking studied by free energy simulations, The Journal of Physical Chemistry B, Volume 125, Issue 51, 2021