@article {366,
	title = {Membrane Remodeling from N-BAR Domain Interactions: Insights from Multi-Scale Simulation},
	journal = {Biophys J},
	volume = {92},
	number = {10},
	year = {2007},
	note = {Ayton, Gary S Blood, Philip D Voth, Gregory A 5 R01 GM063796/GM/NIGMS NIH HHS/United States Research Support, N.I.H., Extramural United States Biophysical journal Biophys J. 2007 May 15;92(10):3595-602. Epub 2007 Feb 26.},
	pages = {3595-602},
	abstract = {<p>Liposome remodeling processes (e.g., vesiculation and tubulation) due to N-BAR domain interactions with the lipid bilayer are explored with a multi-scale simulation approach. Results from atomistic-level molecular dynamics simulations of membrane binding to the concave face of N-BAR domains are used along with discretized mesoscopic field-theoretic simulations to examine how the spontaneous curvature fields generated by N-BAR domains result in membrane remodeling. It is found that tubulation can be generated by anisotropic N-BAR spontaneous curvature fields, whereas vesiculation is only observed with isotropic N-BAR spontaneous curvature fields at high density. The results of the multi-scale simulations provide insight into recent experimental observations.</p>},
	keywords = {Binding Sites Computer Simulation Lipid Bilayers/*chemistry Liposomes/*chemistry *Membrane Fluidity *Models, Chemical *Models, Molecular Molecular Conformation Nerve Tissue Proteins/*chemistry/*ultrastructure Protein Binding Protein Structure, Tertiary},
	doi = {10.1529/biophysj.106.101709},
	author = {Ayton, G. S. and Blood, P. D. and G. A. Voth}
}
