@article {595,
	title = {Extending a Spectrin Repeat Unit. I: Linear Force-Extension Response},
	journal = {Biophys J},
	volume = {90},
	number = {1},
	year = {2006},
	note = {Paramore, Sterling Ayton, Gary S Mirijanian, Dina T Voth, Gregory A Research Support, Non-U.S. Gov{\textquoteright}t Research Support, U.S. Gov{\textquoteright}t, Non-P.H.S. United States Biophysical journal Biophys J. 2006 Jan 1;90(1):92-100. Epub 2005 Oct 14.},
	pages = {92-100},
	abstract = {<p>Nonequilibrium molecular dynamics simulations were used to calculate the elastic properties of a spectrin repeat unit. A contiguous alpha-helical linker was constructed by employing periodic boundary conditions, allowing a novel scheme for evaluating the thermodynamic force as a function of extension. By measuring the force-extension response under small extensions, spectrin was observed to behave primarily as an elastic material with a spring constant of 1700 +/- 100 pN/nm. The implications of this spring constant, in terms of the properties of the spectrin tetramer, are also discussed.</p>},
	keywords = {Algorithms Animals Biophysics/*methods Brain/metabolism Carbon/chemistry Chickens Computer Simulation Cytoskeleton/chemistry Magnetic Resonance Spectroscopy Microscopy, Atomic Force/methods Models, Biological Models, Secondary Software Spectrin/*chemistry/metabolism Thermodynamics Water/chemistry, Statistical Molecular Conformation Protein Conformation Protein Denaturation Protein Folding Protein Structure},
	doi = {10.1529/biophysj.105.066969},
	author = {S. Paramore and Ayton, G. S. and D. T. Mirijanian and G. A. Voth}
}
